Yes!
Heat Tape PRO can be use with any gutter system made, be it open, closed, metal, plastic, vertical or horizontal. Heat Tape PRO will work throughout the winter to keep an ice free path open for water so it can escape and move away from your home.
Keep in mind that if your home has ice dams in addition to ice in your gutters, you will want to install Heat Tape PRO on your roof to address that problem as well. Heat Cable in the gutters alone will not manage problematic ice on the roof surface.